Abstract. We analyzed pathomorphological changes in liver in laboratory rats under complex influence of open coil production. Relation among expression of the pathological changes in liver parenchyma and stroma, and intensity of vibration, noise and dust were revealed. Enhanced influence of production factors more often cause dystrophic and necrobiotic changes development in hepatocytes. Weaken of compensatory reaction of the organism and tendency to decompensation were found out under enhanced influence of production factors.